Mayor Sergei Sobyanin and his wife Irina have got divorced after 28 years together.
"We respect each other and remain on good terms," Sobyanin told Interfax on Friday. "We hope for understanding and ask for our right to privacy to be respected."
Sobyanin's announcement comes less than a year after President Vladimir Putin said that he and his wife Lyudmila were splitting up, in a sure sign that relationships and leadership don't mix well.
The pair tied the knot in February 1986 and became parents later that year when their eldest daughter Anna was born. Their youngest daughter, Olga, was born in 1997.
Pro-Kremlin Sobyanin was appointed mayor in 2010, taking over from long-term city boss Yury Luzhkov.
He then fended off the challenge of opposition leader Alexei Navalny to win September's mayoral election.